��Ī - Nanophotonics Centre

Colour-changing artificial ‘chameleon skin’ powered by nanomachines

sc604 — Wed, 21 Aug 2019 11:14:52 +0000

The material, developed by researchers from the ��Ī, is made of tiny particles of gold coated in a polymer shell, and then squeezed into microdroplets of water in oil. When exposed to heat or light, the particles stick together, changing the colour of the material. The results are reported in the journal Advanced Optical Materials.

In nature, animals such as chameleons and cuttlefish are able to change colour thanks to chromatophores: skin cells with contractile fibres that move pigments around. The pigments are spread out to show their colour, or squeezed together to make the cell clear.

The artificial chromatophores developed by the ��Ī researchers are built on the same principle, but instead of contractile fibres, their colour-changing abilities rely on light-powered nano-mechanisms, and the ‘cells’ are microscopic drops of water.

When the material is heated above 32C, the nanoparticles store large amounts of elastic energy in a fraction of a second, as the polymer coatings expel all the water and collapse. This has the effect of forcing the nanoparticles to bind together into tight clusters. When the material is cooled, the polymers take on water and expand, and the gold nanoparticles are strongly and quickly pushed apart, like a spring.

“Loading the nanoparticles into the microdroplets allows us to control the shape and size of the clusters, giving us dramatic colour changes,” said Dr Andrew Salmon from ��Ī’s Cavendish Laboratory, the study’s co-first author.

The geometry of the nanoparticles when they bind into clusters determines which colour they appear as: when the nanoparticles are spread apart they are red and when they cluster together they are dark blue. However, the droplets of water also compress the particle clusters, causing them to shadow each other and make the clustered state nearly transparent.

At the moment, the material developed by the ��Ī researchers is in a single layer, so is only able to change to a single colour. However, different nanoparticle materials and shapes could be used in extra layers to make a fully dynamic material, like real chameleon skin.

The researchers also observed that the artificial cells can ‘swim’ in simple ways, similar to the algae Volvox. Shining a light on one edge of the droplets causes the surface to peel towards the light, pushing it forward. Under stronger illumination, high pressure bubbles briefly form to push the droplets along a surface.

“This work is a big advance in using nanoscale technology to do biomimicry,” said co-author Sean Cormier. “We’re now working to replicate this on roll-to-roll films so that we can make metres of colour changing sheets. Using structured light we also plan to use the light-triggered swimming to ‘herd’ droplets. It will be really exciting to see what collective behaviours are generated.”

The research was funded by the European Research Council (ERC) and the Engineering and Physical Sciences Research Council (EPSRC).

Reference:
Andrew R Salmon et al. ‘Motile Artificial Chromatophores: Light-Triggered Nanoparticles for Microdroplet Locomotion and Color Change.’ Advanced Optical Materials (2019). DOI: 10.1002/adom.201900951

Researchers have developed artificial ‘chameleon skin’ that changes colour when exposed to light and could be used in applications such as active camouflage and large-scale dynamic displays.

This work is a big advance in using nanoscale technology to do biomimicry

Sean Cormier

Artificial 'chameleon skin'

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Yes

Smallest pixels ever created could light up colour-changing buildings

sc604 — Fri, 10 May 2019 18:00:00 +0000

The colour pixels, developed by a team of scientists led by the ��Ī, are compatible with roll-to-roll fabrication on flexible plastic films, dramatically reducing their production cost. The results are reported in the journal Science Advances.

It has been a long-held dream to mimic the colour-changing skin of octopus or squid, allowing people or objects to disappear into the natural background, but making large-area flexible display screens is still prohibitively expensive because they are constructed from highly precise multiple layers.

At the centre of the pixels developed by the ��Ī scientists is a tiny particle of gold a few billionths of a metre across. The grain sits on top of a reflective surface, trapping light in the gap in between. Surrounding each grain is a thin sticky coating which changes chemically when electrically switched, causing the pixel to change colour across the spectrum.

The team of scientists, from different disciplines including physics, chemistry and manufacturing, made the pixels by coating vats of golden grains with an active polymer called polyaniline and then spraying them onto flexible mirror-coated plastic, to dramatically drive down production cost.

The pixels are the smallest yet created, a million times smaller than typical smartphone pixels. They can be seen in bright sunlight and because they do not need constant power to keep their set colour, have an energy performance that makes large areas feasible and sustainable. “We started by washing them over aluminized food packets, but then found aerosol spraying is faster,” said co-lead author Hyeon-Ho Jeong from ��Ī’s Cavendish Laboratory.

“These are not the normal tools of nanotechnology, but this sort of radical approach is needed to make sustainable technologies feasible,” said Professor Jeremy J Baumberg of the NanoPhotonics Centre at ��Ī’s Cavendish Laboratory, who led the research. “The strange physics of light on the nanoscale allows it to be switched, even if less than a tenth of the film is coated with our active pixels. That’s because the apparent size of each pixel for light is many times larger than their physical area when using these resonant gold architectures.”

The pixels could enable a host of new application possibilities such as building-sized display screens, architecture which can switch off solar heat load, active camouflage clothing and coatings, as well as tiny indicators for coming internet-of-things devices.

The team are currently working at improving the colour range and are looking for partners to develop the technology further.

The research is funded as part of a UK Engineering and Physical Sciences Research Council (EPSRC) investment in the ��Ī NanoPhotonics Centre, as well as the European Research Council (ERC) and the China Scholarship Council.

Reference:
Jialong Peng et al. ‘Scalable electrochromic nanopixels using plasmonics.’ Science Advances (2019). DOI: 10.1126/sciadv.aaw2205

The smallest pixels yet created – a million times smaller than those in smartphones, made by trapping particles of light under tiny rocks of gold – could be used for new types of large-scale flexible displays, big enough to cover entire buildings.

These are not the normal tools of nanotechnology, but this sort of radical approach is needed to make sustainable technologies feasible

Jeremy Baumberg

NanoPhotonics ��Ī/Hyeon-Ho Jeong, Jialong Peng

Electrochromic nanoparticle-on-mirror constructs (eNPoMs)

Yes

How to train your drugs: from nanotherapeutics to nanobots

sc604 — Fri, 23 Jun 2017 15:00:56 +0000

Chemotherapy benefits a great many patients but the side effects can be brutal.

When a patient is injected with an anti-cancer drug, the idea is that the molecules will seek out and destroy rogue tumour cells. However, relatively large amounts need to be administered to reach the target in high enough concentrations to be effective. As a result of this high drug concentration, healthy cells may be killed as well as cancer cells, leaving many patients weak, nauseated and vulnerable to infection.

One way that researchers are attempting to improve the safety and efficacy of drugs is to use a relatively new area of research known as nanothrapeutics to target drug delivery just to the cells that need it.

Professor Sir Mark Welland is Head of the Electrical Engineering Division at ��Ī. In recent years, his research has focused on nanotherapeutics, working in collaboration with clinicians and industry to develop better, safer drugs. He and his colleagues don’t design new drugs; instead, they design and build smart packaging for existing drugs.

Nanotherapeutics come in many different configurations, but the easiest way to think about them is as small, benign particles filled with a drug. They can be injected in the same way as a normal drug, and are carried through the bloodstream to the target organ, tissue or cell. At this point, a change in the local environment, such as pH, or the use of light or ultrasound, causes the nanoparticles to release their cargo.

Nano-sized tools are increasingly being looked at for diagnosis, drug delivery and therapy. “There are a huge number of possibilities right now, and probably more to come, which is why there’s been so much interest,” says Welland. Using clever chemistry and engineering at the nanoscale, drugs can be ‘taught’ to behave like a Trojan horse, or to hold their fire until just the right moment, or to recognise the target they’re looking for.

“We always try to use techniques that can be scaled up – we avoid using expensive chemistries or expensive equipment, and we’ve been reasonably successful in that,” he adds. “By keeping costs down and using scalable techniques, we’ve got a far better chance of making a successful treatment for patients.”

In 2014, he and collaborators demonstrated that gold nanoparticles could be used to ‘smuggle’ chemotherapy drugs into cancer cells in glioblastoma multiforme, the most common and aggressive type of brain cancer in adults, which is notoriously difficult to treat. The team engineered nanostructures containing gold and cisplatin, a conventional chemotherapy drug. A coating on the particles made them attracted to tumour cells from glioblastoma patients, so that the nanostructures bound and were absorbed into the cancer cells.

Once inside, these nanostructures were exposed to radiotherapy. This caused the gold to release electrons that damaged the cancer cell’s DNA and its overall structure, enhancing the impact of the chemotherapy drug. The process was so effective that 20 days later, the cell culture showed no evidence of any revival, suggesting that the tumour cells had been destroyed.

While the technique is still several years away from use in humans, tests have begun in mice. Welland’s group is working with MedImmune, the biologics R&D arm of pharmaceutical company AstraZeneca, to study the stability of drugs and to design ways to deliver them more effectively using nanotechnology.

“One of the great advantages of working with MedImmune is they understand precisely what the requirements are for a drug to be approved. We would shut down lines of research where we thought it was never going to get to the point of approval by the regulators,” says Welland. “It’s important to be pragmatic about it so that only the approaches with the best chance of working in patients are taken forward.”

The researchers are also targeting diseases like tuberculosis (TB). With funding from the Rosetrees Trust, Welland and postdoctoral researcher Dr Íris da luz Batalha are working with Professor Andres Floto in the Department of Medicine to improve the efficacy of TB drugs.

Their solution has been to design and develop nontoxic, biodegradable polymers that can be ‘fused’ with TB drug molecules. As polymer molecules have a long, chain-like shape, drugs can be attached along the length of the polymer backbone, meaning that very large amounts of the drug can be loaded onto each polymer molecule. The polymers are stable in the bloodstream and release the drugs they carry when they reach the target cell. Inside the cell, the pH drops, which causes the polymer to release the drug.

In fact, the polymers worked so well for TB drugs that another of Welland’s postdoctoral researchers, Dr Myriam Ouberaï, has formed a start-up company, Spirea, which is raising funding to develop the polymers for use with oncology drugs. Ouberaï is hoping to establish a collaboration with a pharma company in the next two years.

“Designing these particles, loading them with drugs and making them clever so that they release their cargo in a controlled and precise way: it’s quite a technical challenge,” adds Welland. “The main reason I’m interested in the challenge is I want to see something working in the clinic – I want to see something working in patients.”

Could nanotechnology move beyond therapeutics to a time when nanomachines keep us healthy by patrolling, monitoring and repairing the body?

Nanomachines have long been a dream of scientists and public alike. But working out how to make them move has meant they’ve remained in the realm of science fiction.

But last year, Professor Jeremy Baumberg and colleagues in ��Ī and the University of Bath developed the world’s tiniest engine – just a few billionths of a metre in size. It’s biocompatible, cost-effective to manufacture, fast to respond and energy efficient.

The forces exerted by these ‘ANTs’ (for ‘actuating nano-transducers’) are nearly a hundred times larger than those for any known device, motor or muscle. To make them, tiny charged particles of gold, bound together with a temperature-responsive polymer gel, are heated with a laser. As the polymer coatings expel water from the gel and collapse, a large amount of elastic energy is stored in a fraction of a second. On cooling, the particles spring apart and release energy.

The researchers hope to use this ability of ANTs to produce very large forces relative to their weight to develop three-dimensional machines that swim, have pumps that take on fluid to sense the environment and are small enough to move around our bloodstream.

Working with ��Ī Enterprise, the University’s commercialisation arm, the team in ��Ī's Nanophotonics Centre hopes to commercialise the technology for microfluidics bio-applications. The work is funded by the Engineering and Physical Sciences Research Council and the European Research Council.

“There’s a revolution happening in personalised healthcare, and for that we need sensors not just on the outside but on the inside,” explains Baumberg, who leads an interdisciplinary Strategic Research Network and Doctoral Training Centre focused on nanoscience and nanotechnology.

“Nanoscience is driving this. We are now building technology that allows us to even imagine these futures.”

Read more about research on future therapeutics in Research Horizons magazine.

Nanotechnology is creating new opportunities for fighting disease – from delivering drugs in smart packaging to nanobots powered by the world’s tiniest engines.

Designing these particles, loading them with drugs and making them clever so that they release their cargo in a controlled and precise way: it’s quite a technical challenge.

Mark Welland

Yu Ji

Artist's impression of a nanobot

The text in this work is licensed under a Creative Commons Attribution 4.0 International License. For image use please see separate credits above.

Yes

Liquid light switch could enable more powerful electronics

sc604 — Mon, 08 Aug 2016 14:09:36 +0000

Researchers have built a miniature electro-optical switch which can change the spin – or angular momentum – of a liquid form of light by applying electric fields to a semiconductor device a millionth of a metre in size. Their results, reported in the journal Nature Materials, demonstrate how to bridge the gap between light and electricity, which could enable the development of ever faster and smaller electronics.

There is a fundamental disparity between the way in which information is processed and transmitted by current technologies. To process information, electrical charges are moved around on semiconductor chips; and to transmit it, light flashes are sent down optical fibres. Current methods of converting between electrical and optical signals are both inefficient and slow, and researchers have been searching for ways to incorporate the two.

In order to make electronics faster and more powerful, more transistors need to be squeezed onto semiconductor chips. For the past 50 years, the number of transistors on a single chip has doubled every two years – this is known as Moore’s law. However, as chips keep getting smaller, scientists now have to deal with the quantum effects associated with individual atoms and electrons, and they are looking for alternatives to the electron as the primary carrier of information in order to keep up with Moore’s law and our thirst for faster, cheaper and more powerful electronics.

The ��Ī researchers, led by Professor Jeremy Baumberg from the NanoPhotonics Centre, in collaboration with researchers from Mexico and Greece, have built a switch which utilises a new state of matter called a Polariton Bose-Einstein condensate in order to mix electric and optical signals, while using miniscule amounts of energy.

Polariton Bose-Einstein condensates are generated by trapping light between mirrors spaced only a few millionths of a metre apart, and letting it interact with thin slabs of semiconductor material, creating a half-light, half-matter mixture known as a polariton.

Putting lots of polaritons in the same space can induce condensation – similar to the condensation of water droplets at high humidity – and the formation of a light-matter fluid which spins clockwise (spin-up) or anticlockwise (spin-down). By applying an electric field to this system, the researchers were able to control the spin of the condensate and switch it between up and down states. The polariton fluid emits light with clockwise or anticlockwise spin, which can be sent through optical fibres for communication, converting electrical to optical signals.

“The polariton switch unifies the best properties of electronics and optics into one tiny device that can deliver at very high speeds while using minimal amounts of power,” said the paper’s lead author Dr Alexander Dreismann from ��Ī’s Cavendish Laboratory.

“We have made a field-effect light switch that can bridge the gap between optics and electronics,” said co-author Dr Hamid Ohadi, also from the Cavendish Laboratory. “We’re reaching the limits of how small we can make transistors, and electronics based on liquid light could be a way of increasing the power and efficiency of the electronics we rely on.”

While the prototype device works at cryogenic temperatures, the researchers are developing other materials that can operate at room temperature, so that the device may be commercialised. The other key factor for the commercialisation of the device is mass production and scalability. “Since this prototype is based on well-established fabrication technology, it has the potential to be scaled up in the near future,” said study co-author Professor Pavlos Savvidis from the FORTH institute in Crete, Greece.

The team is currently exploring options for commercialising the technology as well as integrating it with the existing technology base.

Reference:
A. Dreismann et al. ‘A sub-femtojoule electrical spin-switch based on optically trapped polariton condensates.’ Nature Materials (2016). DOI: 10.1038/nmat4722

Researchers have built a record energy-efficient switch, which uses the interplay of electricity and a liquid form of light, in semiconductor microchips. The device could form the foundation of future signal processing and information technologies, making electronics even more efficient.

We’re reaching the limits of how small we can make transistors, and electronics based on liquid light could be a way of increasing the power and efficiency of the electronics we rely on.

Hamid Ohadi

Alexander Dreismann

Polariton fluid emits clockwise or anticlockwise spin light by applying electric fields to a semiconductor chip.